News

Shenzhen HUIANBIO Technology Co., Ltd. is honored to report on the groundbreaking recognition of Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi with the 2025 Nobel Prize in Physiology or Medicine. The award celebrates their pioneering discoveries concerning "peripheral immune tolerance"—revealing how the immune system distinguishes between "self" and "non-self" to prevent attacks on the body's own tissues.

The Nobel Committee's Verdict

"The discoveries by these three scientists are decisive for understanding how the immune system functions and why not everyone suffers from serious autoimmune diseases."

Decoding the Scientific Milestones

🔬 Discovery of Regulatory T Cells
In 1995, Professor Sakaguchi identified a specific cell type that acts as a "police force" within the immune system. These cells monitor and suppress other immune cells, preventing autoimmune diseases. This finding overturned the long-standing dogma that immune tolerance is established solely in the thymus.

🔬 Identification of the Master Gene FOXP3
In 2001, Brunkow and Ramsdell discovered that mutations in the FOXP3 gene cause severe autoimmune disorders (such as IPEX syndrome) in both mice and humans. Sakaguchi subsequently proved that this gene is the master switch controlling the development of Regulatory T cells.

Clinical & Commercial Impact

✨ Revolutionizing Disease Treatment
These discoveries have opened the new field of peripheral immune tolerance, paving the way for advanced therapies in:

• Cancer Immunotherapy

• Autoimmune Diseases (e.g., Rheumatoid Arthritis, Type 1 Diabetes)

• Transplantation Tolerance
  Globally, numerous therapies targeting Regulatory T cells are now entering clinical trials.

✨ Synergy with IVD Innovation
At HUIANBIO, we are closely monitoring the translation of immune tolerance mechanisms into In Vitro Diagnostic (IVD) applications. We are actively exploring the development of detection technologies for related biomarkers to support early diagnosis and precision medicine.

Visualizing the Mechanism

1. Normal Immune Response: Infected cells present virus fragments via HLA proteins → T-cell receptors recognize the threat and activate the immune response.

2. Peripheral Tolerance: Regulatory T cells intervene to stop erroneous attacks → Preventing autoimmune disease.